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目的探讨联合应用丁咯地尔和尼莫地平治疗后循环缺血的近期疗效和对血液动力学及流变学的影响。方法将75例PCI患者随机分为对照组与治疗组,治疗组38例:应用丁咯地尔注射液200mg静脉滴注,1次/d,尼莫地平片40mg,口服,3次/d;对照组37例:应用曲克芦丁注射液600mg静脉滴注,1次/d,地芬尼多片25mg,口服,3次/d。均治疗14d,均于治疗前后进行血液动力学和血液流变学检测。结果治疗组总有效率为94.7%,高于对照组(67.6%),差异有统计学意义(P<0.01);治疗组治疗后的血液动力学及流变学较治疗前及对照组治疗后差异有统计学意义(P<0.01)。结论联合应用丁咯地尔和尼莫地平具有协同作用,治疗PCI效果显著,可改善PCI患者的血液动力学和血液流变学,安全可靠,值得临床推广应用。
Objective To investigate the short-term curative effect and hemodynamic and rheological effects of combined application of buflomedil and nimodipine on ischemic circulation. Methods Seventy-five PCI patients were randomly divided into control group and treatment group. The treatment group included 38 patients treated with buflomedil 200 mg intravenously once daily and nimodipine 40 mg orally 3 times daily. The control group of 37 cases: the application of troxerutin injection 600mg intravenous infusion, 1 / d, dipheniri tablets 25mg, orally, 3 times / d. After 14 days of treatment, hemodynamics and hemorheology were detected before and after treatment. Results The total effective rate of the treatment group was 94.7%, which was higher than that of the control group (67.6%), the difference was statistically significant (P <0.01). The hemodynamics and rheology of the treatment group after treatment were significantly higher than those before and after the treatment The difference was statistically significant (P <0.01). Conclusions Combination of buflomedil and nimodipine has a synergistic effect, and the effect of PCI is significant. It can improve the hemodynamics and hemorheology of patients with PCI, which is safe and reliable and worthy of clinical application.