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目的新伯氏液基薄层细胞学在筛查宫颈癌及癌前病变中的临床应用。方法24786名妇女进行了液基薄层细胞学检查,细胞学评价方法采用TBS(the Bethesda system)分级系统(2001年修订)。结果24786名受检妇女中,不典型鳞状细胞(ASC)和不典型腺细胞(AGC)的阳性率为6.17%,鳞状上皮内低度病变(LSIL)的阳性率为1.70%,鳞状上皮内高度病变(HSIL)的阳性率为0.61%,宫颈癌的发病率为0.11%。41~50岁年龄组的宫颈癌检出率为0.16%,21~30岁年龄组的宫颈癌检出率为0.07%。41~50岁年龄组的SIL检出率为2.77%。41~50岁年龄组与51~60岁年龄组LSIL以上病变的阳性率差异有统计学意义(P<0.01)。广州、东莞、深圳宫颈癌的检出率分别为0.14%、0.12%、0.06%,LSIL以上病变的阳性率分别为2.70%,1.98%,1.93%。结论新伯氏液基薄层细胞学是筛查宫颈癌及癌前病变的一种有效方法,30岁以上妇女要定期进行妇科检查。
Objective To evaluate the clinical application of neo-Burgo-based thin-layer cytology in the screening of cervical cancer and precancerous lesions. Methods Totally 24786 women underwent liquid-based thin-layer cytology. Cytology was assessed using the TBS (the Bethesda system) grading system (revised in 2001). Results The positive rate of atypical squamous cell (ASC) and atypical glandular cell (AGC) was 6.17% in 24 786 women and 1.70% in LSIL. The positive rate of squamous epithelium The positive rate of HSIL was 0.61%, and the incidence of cervical cancer was 0.11%. The detection rate of cervical cancer in the 41-50 age group was 0.16%, and the detection rate of cervical cancer in the 21-30 age group was 0.07%. The SIL detection rate in the 41-50 age group was 2.77%. There were significant differences in the positive rates of LSIL between the age group of 41 ~ 50 and the age group of 51 ~ 60 (P <0.01). The detection rates of cervical cancer in Guangzhou, Dongguan and Shenzhen were 0.14%, 0.12% and 0.06% respectively. The positive rates of LSIL lesions were 2.70%, 1.98% and 1.93% respectively. Conclusion Newberger’s liquid-based lamellar cytology is an effective method for screening cervical cancer and precancerous lesions. Women over the age of 30 should undergo regular gynecological examinations.