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作者对45例急性原单细胞白血病(AMOL)进行临床研究。按FAB分类和细胞化学染色,区分了本组分化差的AMOLM_5(a)(25例)和分化好的AMOLM_5(b)(20例)。临床征象 AMOL两性分布频度相同,女性22例,男性23例。年龄4个月～90岁。M_5(a)和M_5(b)的中数年龄分别为33和44岁。82%病例见到髓外浸润,常累及非造血组织,为突出的临床表现。包括皮肤浸润14例,牙龈增生17例,脑膜病变3例,淋巴结、脾和肝肿大者各1例。M_5(b)亚型病例,髓外侵犯并不比M_5(a)多。实验室检查白细胞数(WBC)过多的发生率高,77%的病例WBC>10×10~9/L,35%的病例WBC>100×10~9/L,许多白细胞过多的病例由于白细胞壅滞,早期死于脑或肺病变。血中原粒细胞百分数不等,常见贫血和血小板减少。31例细胞遗传学研
The authors conducted a clinical study of 45 patients with acute primary single-cell leukemia (AMOL). According to FAB classification and cytochemical staining, the poorly differentiated AMOLM_5 (a) (25 cases) and well-differentiated AMOLM_5 (b) (20 cases) were distinguished. Clinical signs AMOL gender distribution frequency of the same, 22 females, 23 males. 4 months old to 90 years old. The median ages of M_5 (a) and M_5 (b) are 33 and 44 respectively. 82% cases of extramedullary infiltration, often involving non-hematopoietic tissue, as a prominent clinical manifestations. Including skin infiltration in 14 cases, gingival hyperplasia in 17 cases, 3 cases of meningeal lesions, lymph nodes, spleen and hepatomegaly in 1 case. M_5 (b) subtype cases, extramedullary invasion is not more than M_5 (a). The high prevalence of laboratory white blood cell count (WBC) was high in 77% of patients with WBC> 10 × 10-9 / L, 35% of patients with WBC> 100 × 10-9 / L, and many cases of leukocytosis Leukocyte stagnation, early death in brain or lung disease. Blood neutrophil percentage, ranging from common anemia and thrombocytopenia. 31 cases of cytogenetics research