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血清流行病学就是分析人群血清中特异性抗体,阐明人群免疫水平与疾病流行的关系,也就是应用血清学方法研究疾病的流行病学问题。人体感染霍乱弧菌后发生抗菌和抗毒免疫反应并产生相应的血清抗体。杀弧菌抗体通常在感染后迅速出现并于第10天左右达到高峰,1个月后轻度下降,6～12个月后明显下降,13～19个月时下降到感染前的水平;血清抗毒素于感染后1个月时明显升高,持续19～25个月。隐性感染者血清抗毒素和杀弧菌抗体水平与临床病人相
Serological epidemiology is the analysis of human serum-specific antibodies to clarify the relationship between population immunity and the epidemic, which is the application of serological methods to study the epidemiological problems of the disease. After the human body has infected with Vibrio cholerae, antibacterial and anti-toxin immune reactions occur and the corresponding serum antibodies are produced. Vibrio cholerae antibodies usually appear rapidly after infection and peak around day 10, with a slight decrease after 1 month, a significant decrease after 6 to 12 months, and a pre-infection level from 13 to 19 months; serum Antitoxin was significantly increased at 1 month after infection for 19 to 25 months. Totally infected patients with serum anti-toxin and anti-Vibrio antimicrobial antibody levels and clinical phase