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目的 观察胃癌患者血浆可溶性 P-选择素 (s P- se-lectin)和血清唾液酸 (SA)水平 ,探讨其临床意义 .方法 用EL ISA法和快速比色法分别测定 4 5例胃癌患者 ,4 0例胃溃疡患者及 30例正常人血浆 s P- selectin和血清 SA水平 .结果 胃癌患者血浆 s P- selectin水平 (110± 6 ) mg· L- 1 及血清SA水平 (94 0± 5 2 ) mg· L- 1 显著高于胃溃疡患者 (2 3± 3) mg· L- 1 ,(5 80± 4 7) mg·L- 1及正常人群 (2 1± 5 ) mg·L- 1 ,(5 5 0± 38) mg· L- 1 (P<0 .0 1,P<0 .0 1) ;胃癌患者 s P- selectin水平有脏器转移者 (12 1± 4 ) mg· L- 1 与无脏器转移者 (10 4± 3)mg·L- 1比较差异有显著性 (P<0 .0 5 ) ,而胃溃疡患者与正常人群之间比较无统计学意义 (P>0 .0 5 ) .结论 s P- selectin和 SA均参与了胃癌的发生发展 ,两指标对于良、恶性溃疡的鉴别有一定价值 .另外 ,s P- selectin还可作为有无转移的一项辅助指标 .
Objective To observe the levels of plasma s-se-lectin and sialic acid (SA) in patients with gastric cancer and to explore its clinical significance.Methods ELSA and rapid colorimetric assay were used to detect 45 cases of gastric cancer, The plasma levels of s-selectin and serum SA in 40 patients with gastric ulcer and 30 normal individuals were determined.Results The levels of plasma s-selectin (110 ± 6) mg · L- 1 and serum SA in gastric cancer patients (94 ± 5 2 ) mg · L-1 was significantly higher than that of patients with gastric ulcer (23 ± 3) mg · L -1, (58 ± 4 ± 7) mg · L -1, and normal population (21 ± 5) mg · L -1 , (P <0.05), (54.0 ± 38) mg · L -1 (P <0.01, P <0.01). The levels of s-selectin in gastric cancer patients were (12 1 ± 4) mg · L - 1 compared with those without organ metastasis (104 ± 3) mg · L -1 (P <0.05), but there was no significant difference between gastric ulcer patients and normal controls (P> 0 .0 5) .Conclusion Both s-selectin and SA are involved in the development of gastric cancer, and the two indexes have some value for the differentiation of benign and malignant ulcers.In addition, s P-selectin can also be used as an aid in metastasis Indicators.