论文部分内容阅读
造血生长因子通过与其受体的相互作用调节血细胞的增殖与分化。造血生长因子与受体结合后激活JAK,JAK发生自我磷酸化的同时也使受体磷酸化,继而通过SH2 蛋白激活ras通路。JAK还可以使STAT磷酸化。STAT磷酸化后移到细胞核内,启动有关基因的转录。
Hematopoietic growth factor regulates the proliferation and differentiation of blood cells through its interaction with its receptor. Upon binding of hematopoietic growth factor to the receptor, JAK is activated. JAK autophosphorylation also phosphorylates the receptor, which in turn activates the ras pathway through the SH2 protein. JAK also phosphorylates STAT. STAT phosphorylation moved to the nucleus, start the transcription of the gene.