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内皮细胞不仅仅是血管腔内的一层防护细胞 ,而且还能分泌一系列血管活性物质 ,参与多种生理及病理过程。生理状态下能调节血管壁紧张度、抗炎、抗栓、抑制血管平滑肌增殖等保护作用。当其受损或激活时 ,内皮细胞的功能障碍 ,从而影响血管紧张度、血管炎性改变、斑块易损及血栓形成。因此内皮细胞功能障碍与动脉粥样硬化、高血压、急性冠脉综合征及心力衰竭等心血管疾病的发生、发展有密切关系。对内皮功能障碍进行检测及逆转性治疗 ,已成为心血管领域的一个新的研究热点及治疗趋势。目前主要的检测方法包括冠脉内乙酰胆碱法 ,肱动脉超声法。主要治疗措施包括 :抗氧化剂、一氧化氮前体物L 精氨酸、叶酸及雌激素、血管紧张素转化酶抑制剂、他汀类、螺内酯等
Endothelial cells are not only a layer of protective cells in the vascular lumen, but also secrete a series of vasoactive substances, involved in a variety of physiological and pathological processes. Physiological state can regulate the tension of the vascular wall, anti-inflammatory, antithrombotic, inhibition of vascular smooth muscle proliferation and other protective effect. When it is damaged or activated, endothelial cells are dysfunctional, affecting vascular tone, vascular inflammatory changes, plaque vulnerability and thrombosis. Therefore, endothelial dysfunction and atherosclerosis, hypertension, acute coronary syndromes and heart failure and other cardiovascular diseases are closely related. Endothelial dysfunction detection and reversal of treatment, has become a new area of cardiovascular research and treatment trends. At present, the main detection methods include intra-coronary acetylcholine method, brachial artery ultrasound. The main treatments include: antioxidants, nitric oxide precursor L-arginine, folic acid and estrogen, angiotensin converting enzyme inhibitors, statins, spironolactone etc.