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杂环位于氨基酸C-末端羧基与α-碳之间的α-五元杂环氨基酸是一类主要来源于海洋多肽的高度修饰的氨基酸,分子中杂环的存在对化合物的生物活性有着重要的影响.综述了此类氨基酸的合成方法,这些方法针对不同的底物在操作简便性、收率、产物光学纯度、适用范围上有着明显差别.
Heterocycles A-5-membered heterocyclic amino acids located between the C-terminal carboxyl group and the α-carbon of the amino acids are a class of highly modified amino acids mainly derived from marine polypeptides. The presence of heterocycles in the molecule is important for the biological activity of the compounds The methods for the synthesis of these amino acids are reviewed. These methods are obviously different from each other in terms of ease of operation, yield, optical purity of the product and applicable scope.