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去甲斑蝥素(norcantharidin,NCTD)是从传统中药斑蝥中提取出的新型抗肿瘤药物,目前主要用于消化道肿瘤,肝癌,白细胞减少症等疾病的治疗。肿瘤的发生机制十分复杂,目前认为肿瘤不仅是增殖和分化异常的疾病,同时也是凋亡异常的疾病,所以诱导肿瘤细胞发生凋亡已成为目前肿瘤治疗的新的途径。NCTD对肿瘤细胞抑制作用的机制尚未完全阐明,但现有的很多研究表明,NCTD对许多肿瘤细胞起抑制作用主要体现在诱导肿瘤细胞凋亡方面,从而使恶性肿瘤达到临床缓解及治愈。本文就NCTD诱导恶性肿瘤细胞凋亡机制的研究做一简要综述。
Norcantharidin (NCTD) is a new antitumor drug extracted from the traditional Chinese medicine Mackerel, which is mainly used for the treatment of gastrointestinal cancer, liver cancer, leucopenia and other diseases. The mechanism of tumor occurrence is very complicated. At present it is considered that tumor is not only a disease with abnormal proliferation and differentiation, but also a disease with abnormal apoptosis. Therefore, inducing apoptosis of tumor cells has become a new way of tumor treatment at present. The mechanism of NCTD on tumor cells has not yet been fully elucidated, but many studies have shown that NCTD can inhibit many tumor cells mainly in inducing tumor cell apoptosis, so that malignant tumors can achieve clinical remission and cure. In this paper, a brief review on the mechanism of apoptosis induced by NCTD in malignant tumor cells is summarized.