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目的分析河北省疑似预防接种异常反应(Adverse Events Following I mmunization,AEFI)发生特征,评价AEFI监测系统运转状况、疫苗的安全性和预防接种服务质量。方法通过中国免疫规划监测信息管理系统收集全省报告的2005~2007年AEFI个案数据,采用描述性方法对相关指标进行流行病学分析。结果河北省2005~2007年报告AEFI1466例,一般反应和异常反应占93.79%,偶合症次之,其它原因极少;全省99.43%的县报告了AEFI;≤1岁儿童占2/3。每年4~11月发生较多,以百日咳-白喉-破伤风联合疫苗、麻疹减毒活疫苗和第1剂接种为主。临床损害以发热、无菌性脓肿和过敏性反应最为多见。AEFI发生率在预期发生率范围之内;AEFI报告发生率为23.34/100万剂,完整率为95.48%,及时报告率为84.99%,及时调查率为71.62%。结论疫苗的安全性和预防接种服务质量良好。全省AEFI监测的完整性和及时性较好,但完整性和调查及时性需进一步提高。
Objective To analyze the characteristics of AEFI in Hebei Province and evaluate the operation status of AEFI monitoring system, the safety of vaccines and the quality of vaccination services. Methods The data of AEFI cases collected from 2005 to 2007 in the province were collected through the China Immunization Program Monitoring Information Management System, and the descriptive method was used to analyze the epidemiological indexes. Results A total of 1466 cases of AEFI were reported in Hebei province from 2005 to 2007, accounting for 93.79% of common reactions and abnormal reactions. The incidence of secondary diseases was the second, with few other reasons. AEFI was reported in 99.43% of the counties in the province and 2/3 of children ≤1 years. Occur from April to November each year, with pertussis - diphtheria - tetanus vaccine, live attenuated measles vaccine and the first dose of the main. Clinical damage to fever, aseptic abscesses and allergic reactions most commonly seen. The incidence of AEFI was within the expected incidence rate. The incidence of AEFI was 23.34 / 1 million doses, the complete rate was 95.48%, the timely reporting rate was 84.99% and the timely investigation rate was 71.62%. Conclusion The vaccine safety and vaccination services are of good quality. The integrity and timeliness of the AEFI monitoring in the province are good, but integrity and timeliness of investigation need to be further improved.