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目的 探讨慢性肝炎患者血清Ⅲ型前胶原 (PCⅢ )与其肝组织纤维化病理分期的相关性。方法 随机选择在我院住院的慢性肝炎患者 10 0例为实验组 ,抽取其静脉血检测血清PCⅢ含量 ,并行肝组织活检 ,病理检查。同时选择 40例体检正常者作对照组。结果 两组血清PCⅢ含量间的差别有显著性意义 (P <0 0 1) ;不同期的肝组织纤维化患者其血清PCⅢ含量间的差别有显著性意义 (P <0 0 5 ) ;肝组织纤维化分期与PCⅢ含量之间呈显著正相关 (r=0 86 ,P <0 0 5 )。结论 肝组织纤维化病理分期越高 ,血清PCⅢ含量亦越高 ,故血清PCⅢ可作为观察慢性肝炎肝组织纤维化分期的指标
Objective To investigate the relationship between serum type Ⅲ procollagen (PC Ⅲ) and pathological stage of hepatic fibrosis in patients with chronic hepatitis. Methods One hundred patients with chronic hepatitis who were hospitalized in our hospital were randomly selected as the experimental group. The venous blood samples were collected to detect the serum PCⅢ levels, and the liver biopsy and pathological examination were performed. At the same time select 40 cases of physical examination as a control group. Results There was a significant difference in serum PCⅢ levels between the two groups (P <0.01). There was a significant difference in serum PCⅢ levels between different stages of liver fibrosis (P <0.05) There was a significant positive correlation between fibrosis stage and PCⅢ level (r = 0 86, P 0 05). Conclusions The higher the pathological stage of liver fibrosis, the higher the serum PCⅢ level, so serum PC Ⅲ can be used as an indicator to observe the liver fibrosis staging of chronic hepatitis