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为观察米非司酮配伍利凡诺的中期妊娠引产作用,选择60例欲行利凡诺羊膜腔内注射法中期引产的孕妇,随机分为两组,各30例,米非司酮组于利凡诺引产前36,24,12小时口服米非司酮50mg,共三次;对照组单纯利凡诺引产。观察两组引流产进程及分娩阵痛情况,并于腔内注射时抽取羊水,放免法检测雌二醇(E_2)及孕酮(P)水平。米非司酮组腔内注射至产程发动时间,产程发动至胎儿娩出时间短于对照组,流产过程中阵痛程度减轻,差异均有统计学意义;羊水中E_2水平升高(P<0.05),P水平无明显变化(P>0.05)。治疗过程中无严重副作用发生。米非司酮用于利凡诺羊膜腔内注射法中期引产可加速引流产进程及减轻分娩阵痛,从而提高引产质量。
To observe the effects of mifepristone and rivanol on induction of labor in the second trimester of pregnancy, 60 pregnant women who were induced by mid-term induction of amiodarone via amifostine were randomly divided into two groups (30 in each group, mifepristone group) Ribavirin induction of labor 36,24,12 hours before oral administration of mifepristone 50mg, a total of three times; control group only rivanol induced labor. The process of drainage and childbirth were observed in both groups. Amniotic fluid was drawn during intracavitary injection. The levels of estradiol (E2) and progesterone (P) were determined by radioimmunoassay. Mifepristone group intra-articular injection of labor to start time, labor to fetal delivery time is shorter than the control group, abortion, reduce the pain degree, the difference was statistically significant; amniotic fluid levels of E 2 (P <0.05) P level no significant change (P> 0.05). No serious side effects occurred during treatment. Mifepristone for rivano intra-amniotic injection mid-term induction of labor can speed up the drainage process and reduce labor pain, thereby enhancing the quality of labor.