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卵巢过激综合征(OHSS)是超促排卵过程中发生的一种严重并发症,其基本病理生理学改变为毛细血管通透性急剧增加。对血管内皮生长因子(VEGF,又称血管渗透因子)与重度OHSS的关系进行研究。 7例重度OHSS患者,卵巢大小平均12.5±1.3cm,合并大量腹水,4例同时合并胸水。红细胞压积(HCT)平均值42.3％±1.1％,白细胞(WBC)计数平均23100±2900/mm~3,血浆雌二醇(E_2)水平显著升高,平均17217±1982pmol/L,4例有中重度胃肠道症状,包括腹泻和/或呕吐。对照组包括7例经促排卵但未发生OHSS的健康妇女,两组有可比性。
Ovarian hyperstimulation syndrome (OHSS) is a serious complication in the process of hyperstimulation, and its basic pathophysiology is the sharp increase of capillary permeability. The relationship between vascular endothelial growth factor (VEGF), also known as vascular permeability factor, and severe OHSS was studied. Seven patients with severe OHSS had an average ovarian size of 12.5 ± 1.3 cm with a large amount of ascites and 4 with pleural effusion. The average value of hematocrit (HCT) was 42.3% ± 1.1%, the count of WBC was 23100 ± 2900 / mm ~ 3, the level of plasma estradiol (E_2) was significantly increased, with an average of 17217 ± 1982pmol / L Moderate to severe gastrointestinal symptoms, including diarrhea and / or vomiting. The control group consisted of 7 healthy women who had ovulation induced but did not develop OHSS, and the two groups were comparable.