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深静脉血栓形成必须及时治疗,作者扼要地介绍抗凝剂与纤溶药物的应用及其疗效。肝素:肝素的抗凝作用是通过对抗凝血酶Ⅲ的致活、加速抗凝血酶与凝血酶以及因子Ⅸ、Ⅹ,Ⅺ、Ⅻ的结合,从而抑制正常的凝血过程。某些广泛血栓形成的病人需用超大剂量,这可能与血栓形成过程中对抗肝素的血小板因子4释放增加有关。肝素抗凝的半衰期不到2小时,故连续静脉滴注较间断静脉给药为佳,其初导剂量为3,000～6,000单位,以后维持1,200
Deep venous thrombosis must be promptly treated, the author briefly describes the application of anticoagulants and fibrinolytic drugs and its efficacy. Heparin: The anticoagulant effect of heparin suppresses normal clotting by inhibiting the activity of thrombin III and accelerating the binding of antithrombin to thrombin and factors Ⅸ, Ⅹ, Ⅺ and Ⅻ. Some patients with extensive thrombosis require overdosage, which may be related to the increased release of platelet factor 4 against heparin during thrombosis. The half-life of heparin anticoagulation less than 2 hours, so continuous intravenous infusion of intermittent intravenous injection is better, the initial dose of 3,000 to 6,000 units, and later maintained at 1,200