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目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)细胞毒素相关蛋白A(CagA)在动脉粥样硬化性脑梗死患者血清中的表达。方法对脑梗死组65例患者的中性粒细胞、血纤维蛋白原、hsCRP及CagA-Hp-IgG抗体进行测定,采用超声检测颈部血管,所有检测结果与健康对照组进行比较。结果研究组与对照组血清CagA-Hp抗体阳性率分别为60%和32%;H.pylori抗体阳性组较阴性组相比,血hs-CRP和纤维蛋白原升高明显(t=4.872,P<0.05;t=1.982,P<0.05);H.pylori抗体阳性者狭窄及颈动脉斑块发生率分别为53.8%和89.7%,与对照组的26.9%和53.8%相比差异具有统计学意义(χ2=5.826和6.297,P均<0.05)。结论动脉粥样硬化性脑梗死患者的H.pylori感染率高于健康人,H.pylori感染可能与脑梗死的发生有关。
Objective To investigate the expression of Helicobacter pylori (Hpylori) cytotoxin-related protein A (CagA) in serum of atherosclerotic cerebral infarction patients. Methods The neutrophil, fibrinogen, hsCRP and CagA-Hp-IgG antibodies were detected in 65 patients with cerebral infarction. The neck vessels were detected by ultrasound. All the test results were compared with those of healthy controls. Results The positive rates of serum CagA-Hp antibody in study group and control group were 60% and 32%, respectively. Compared with negative group, serum hs-CRP and fibrinogen were significantly increased in H.pylori-positive group (t = 4.872, P <0.05; t = 1.982, P <0.05). The prevalence of stenosis and carotid plaque in positive H.pylori antibody were 53.8% and 89.7%, respectively, which were significantly different from those in control group (26.9% and 53.8%) (χ2 = 5.826 and 6.297, P <0.05). Conclusions The H.pylori infection rate in patients with atherosclerotic cerebral infarction is higher than that in healthy people, and H.pylori infection may be related to the occurrence of cerebral infarction.