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体外培养人脐静脉内皮细胞（ＨＵＶＥＣ），主要研究：①内毒素损伤内皮细胞过程中一氧化氮（ＮＯ）的作用；②不同浓度ＮＯ供体ＳＩＮ－１（３－ｍｏｒｐｈｏｌｉｎｏｓｙｄｎｏｎｉｍｉｎｅ）对内皮细胞的作用以及ＳＯＤ、ＣＡＴ对内皮细胞的保护作用。结果提示：ＮＯ在内毒素损伤内皮细胞过程中发挥重要作用；高浓度ＳＩＮ－１可严重损伤内皮细胞；ＳＯＤ、ＣＡＴ对内皮细胞的不同保护作用说明ＯＮＯＯ－的产生可能是ＮＯ损伤内皮细胞的重要机制
In vitro culture of human umbilical vein endothelial cells (HUVEC), the main research: ① endotoxin damage endothelial cells during the role of nitric oxide (NO); ② different concentrations of NO donor SIN-1 (3-morpholinosydnonimine) on endothelial cells And the protective effects of SOD and CAT on endothelial cells. The results suggest that NO plays an important role in the process of endothelial cell injury induced by endotoxin. High concentrations of SIN-1 can seriously damage endothelial cells. Different protective effects of SOD and CAT on endothelial cells suggest that the production of ONOO- may be an important factor that NO damages endothelial cells mechanism