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目的:制备冬凌草甲素亚微乳,并对其理化性质进行表征。方法:采用高压均质法制备冬凌草甲素亚微乳,并对其粒径、Zeta电位、黏度等性质进行表征。结果:冬凌草甲素亚微乳为白色不透明乳状液体,载药量1g·L-1,平均粒径(138.87±0.60)nm,Zeta电位(47.27±2.31)mV,pH(6.02±0.03),黏度(1.78±0.015)MPa.s。结论:本实验所制得的冬凌草甲素亚微乳理化性质较稳定,工艺简单,可为冬凌草甲素亚微乳制剂的制备提供研究依据。
Objective: To prepare submicroemulsion of oridonin and characterize its physicochemical properties. Methods: Oridonin microemulsion was prepared by high-pressure homogenization and characterized by its particle size, Zeta potential and viscosity. RESULTS: Oridonin submicroemulsion was a white opaque milky liquid with a drug loading of 1 g·L-1, average particle size (138.87±0.60) nm, Zeta potential (47.27±2.31) mV, pH (6.02±0.03). , Viscosity (1.78 ± 0.015) MPa.s. Conclusion: The physical and chemical properties of Oridonin submicroemulsion obtained in this experiment are stable and the process is simple. It can provide research basis for the preparation of Oridonin submicroemulsion preparation.