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(www.colorcon.com.cn)渗透泵产品的制备是比较困难的。这些产品中含有高用量的亲水聚合物,在药物层中起到容纳和夹带药物的作用,而在推动层中可以产生极高的膨胀力将药物层从渗透泵片的释药孔推挤出去。在这些制剂中使用的主要聚合物就是保益乐~(TM)(POLYOX~(TM))(聚氧乙烯)。聚氧乙烯是水溶性树脂,它可以快速地水化产生黏稠的凝胶。它可以塑性形变,熔点低(约68℃),有黏弹性。这些特征在我们试图使用通常的制粒和压片技术时会出现问题。
(www.colorcon.com.cn) osmotic pump product preparation is more difficult. These products contain a high amount of hydrophilic polymer that acts as a medicament for containing and entraining the drug layer, while creating an extremely high expansion force in the push layer to push the drug layer from the release hole in the osmotic pump chip Go out The main polymer used in these formulations is Polyox (TM) (Polyoxyethylene). Polyoxyethylene is a water-soluble resin that hydrates rapidly to produce a sticky gel. It can be plastic deformation, low melting point (about 68 ℃), a viscoelastic. These features can cause problems when we try to use the usual granulation and tabletting techniques.