论文部分内容阅读
目的:探讨2种剂量来曲唑(LE)与克罗米芬(CC)对多囊卵巢综合征(PCOS)患者子宫卵巢血流动力学的影响。方法:2种剂量LE与CC治疗90例PCOS不孕症患者,随机分CC组(A组,n=32,50 mg/d)、低剂量LE组(B组,n=30,2.5 mg/d)和高剂量LE组(C组,n=28,5.0 mg/d)。同时以28例正常育龄妇女作为对照组(D组)。经阴道超声监测子宫卵巢血流的参数,比较排卵率、妊娠率。结果:①LE的2个剂量组子宫卵巢血流均出现类似正常育龄妇女的周期性血流变化;②C组方案治疗PCOS有较高的排卵率和妊娠率。结论:来曲唑改善了PCOS患者的子宫卵巢血流供应,5.0 mg可能有更好的促排卵效果。
Objective: To investigate the effects of two doses of letrozole (LE) and clomiphene citrate on the ovarian hemodynamics in women with polycystic ovary syndrome (PCOS). Methods: 90 patients with PCOS infertility were treated with two doses of LE and CC. Patients in CC group (group A, n = 32, 50 mg / d) and low dose LE group (group B, n = 30 and 2.5 mg / d) and high dose LE group (group C, n = 28, 5.0 mg / d). At the same time, 28 normal women of childbearing age were used as the control group (group D). Transvaginal ultrasound monitoring of uterine ovarian blood flow parameters, comparison of ovulation rate, pregnancy rate. Results: ① The blood flow of uterine ovary in 2 doses of LE both showed the similar changes of the periodic blood flow in women of childbearing age. ② The PCOS of group C had higher ovulation rate and pregnancy rate. Conclusion: Letrozole improves uterine ovarian blood flow in patients with PCOS, and 5.0 mg may have a better ovulation promoting effect.