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目的 探讨抑癌基因P53 Codon 72多态性与HPV有关的宫颈癌的关系。 方法 应用聚合酶链反应法分别对30例卵巢浆液性囊腺癌、50例宫颈鳞状细胞癌和30例正常妇女的P53 Codon 72多态性进行检测。 结果 P53 Arg纯合子、P53 Arg/P53 Pro杂合子和P53Pro纯合子正常妇女对照组分别为33.3％、60％和6.7％;而在卵巢癌组分别为40％、53.3％和6.7％;在宫颈癌组分别为80％、14％和6％。上述人群中,宫颈癌P53 Arg纯合子明显高于卵巢癌组和正常妇女对照组(P<0.05)。 结论 p53 Arg纯合子可作为与HPV感染有关的宫颈癌的危险因素。
Objective To investigate the relationship between P53 Codon 72 polymorphism and HPV-related cervical cancer. Methods The P53 Codon 72 polymorphism of 30 cases of ovarian serous cystadenocarcinoma, 50 cases of cervical squamous cell carcinoma and 30 normal women were detected by polymerase chain reaction. Results The normal control group of P53 Arg homozygotes, P53 Arg / P53 Pro heterozygotes and P53Pro homozygotes were 33.3%, 60% and 6.7% respectively, while in ovarian cancer group they were 40%, 53.3% and 6.7% Cancer groups were 80%, 14% and 6% respectively. Among the above groups, homozygote of P53 Arg in cervical cancer was significantly higher than that in ovarian cancer group and normal women (P <0.05). Conclusion The homozygous p53 Arg can be used as a risk factor for cervical cancer associated with HPV infection.