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羰基化合物的不对称氰醇化反应是当前不对称催化领域里的一个研究热点.具有光学活性的氰醇是有机合成的重要中间体,通过官能团转化可以很容易制备出一些在天然产物和化学制药中具有重要意义的手性化合物,如β-氨基醇、α-氨基酸和α-羟基酸等.目前,不对称催化的三甲基氰硅烷与醛酮的加成反应作为手性氰醇的主要化学合成方法受到人们的广泛关注,而反应体系中采用的手性配体与Lewis酸是控制这类反应的效能和立体选择性的关键,因此,主要就三甲基氰硅烷和醛酮不对称加成反应中催化体系的发展作了一个简要的述评.
Asymmetric cyanohydrin reaction of carbonyl compounds is one of the hot topics in the field of asymmetric catalysis.An optically active cyanohydrin is an important intermediate in organic synthesis and can be easily prepared by functional group conversion in natural products and pharmaceuticals Significant chiral compounds, such as β-amino alcohols, α-amino acids and α-hydroxy acids, etc. At present, the asymmetric catalytic addition of trimethylsilyl cyanide to aldehydes and ketones is the main chemistry of chiral cyanohydrin The synthesis method is widely concerned by people. The chiral ligand and Lewis acid used in the reaction system are the key factors to control the efficiency and stereoselectivity of these reactions. Therefore, the asymmetric addition of trimethylsilyl cyanide and aldehydes and ketones Into the reaction of the catalytic system made a brief comment on the development.