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目的探讨HBV感染母亲HBIG产前阻断所产新生儿HBV感染情况。方法以HBIG产前阻断的新生儿出生静脉血定量检测新生儿乙肝病毒标志物。将乙肝血清标志物阳性的109例孕妇分为孕期阻断组(阻断组)48例和孕期非阻断组(非阻断组)61例,阻断组孕28周起每4周肌肉注射高效乙肝免疫球蛋白200IU,共3针;非阻断组孕期未注射乙肝免疫球蛋白,观察新生儿股静脉血乙肝病毒标志物并进行对比观察。结果阻断组和非阻断组新生儿静脉血乙肝血清标志物阳性率分别为:HBsAg阳性率6.25%(3/48);9.84%(6/61),HBeAg阳性率47.9%(20/48);34.4%(21/61),HBV-DNA阳性率6.25%(3/48);13.11%(8/61),抗-HBs阳性率27.1%(13/48);14.7%(9/61)。结论孕晚期注射乙肝免疫蛋白被动免疫方式对阻断乙肝病毒母婴传播具有重大作用,减少了母婴垂直传播(宫内感染)的发生率,减少了乙肝传播。
Objective To investigate the HBV infection of neonates with HBIG produced by HBV infected mothers. Methods Newborns hepatitis B virus markers were detected by neonatal venous blood with HBIG prenatal occlusion. The 109 pregnant women with positive serum HBV markers were divided into two groups: 48 in pregnancy block (blocking group) and 61 in non-blocking group (non-blocking group) High-efficiency hepatitis B immunoglobulin 200IU, a total of 3-needle; non-blocking group did not inject hepatitis B immunoglobulin during pregnancy, observation of neonatal femoral vein blood HBV markers and comparative observation. Results The positive rate of serum HBsAg in neonates with and without block was 6.25% (3/48), 9.84% (6/61) and 47.9% (20/48) respectively ), 34.4% (21/61), the positive rate of HBV DNA was 6.25% (3/48), 13.11% (8/61), the positive rate of anti-HBs was 27.1% (13/48) ). Conclusion The passive immunization of hepatitis B immune protein during the third trimester of pregnancy is of great importance in blocking mother-to-child transmission of hepatitis B virus, reducing the incidence of vertical transmission (intrauterine infection) and reducing the spread of hepatitis B virus.