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磷酸双异丙吡胺(Disopyramide phosphate,Norpace)为最近应用于临床的一种抗心律失常药物。它具有膜抑制和抗胆硷能两种作用。在人的电生理学研究中,通常能使心房、心室和房室束—浦肯野系统的自发周期长度缩短,相对不应期轻度延长,并使P波和QRS综合波增宽。它不影响房室结的传导时间,但可延长房室束—浦肯野系统的传导时间。其大多数作用与药物浓度有关。全部的抑制作用可被其伴有的抗胆硷能特性所消除。该药用于窦房结功能不全
Disopyramide phosphate (Noropy) is an anti-arrhythmic drug recently applied to the clinic. It has both membrane inhibition and anti-cholinergic effects. In human electrophysiology studies, the spontaneous periodicity of the atrial, ventricular and atrioventricular bundle-Purkinje systems is usually shortened, the relative refractory period is slightly prolonged, and the P-wave and QRS complex are broadened. It does not affect the AV node conduction time, but can extend the atrioventricular bundle - Purkinje system conduction time. Most of its role and drug concentration. The overall inhibitory effect can be counteracted by the anticholinergic properties associated with it. This medicine is used for sinus node dysfunction