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目的 :通过检测血浆 5 羟色胺 (5 HT)水平 ,初步探讨儿童孤独症的生化病理机制。 方法 :采用放射免疫方法定量检测 5 4例儿童孤独症患儿 (病例组 )及 2 6名健康儿童 (对照组 )的血浆 5 HT水平 ,并作比较。 结果 :病例组的血浆 5 HT水平显著高于对照组 ,但与疾病的严重程度无明显相关。 结论 :提示高 5 HT可能是儿童孤独症生物学标志。
OBJECTIVE: To investigate the biochemical and pathological mechanism of autism in children by detecting the level of serotonin (5 HT) in children. Methods: Radioimmunoassay was used to detect the level of 5 HT in 54 children with autism (case group) and 26 healthy children (control group). Results: The level of plasma 5 HT in the case group was significantly higher than that in the control group, but no significant correlation was found with the severity of the disease. Conclusion: It is suggested that high 5 HT may be a biological marker of autism in children.