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给９日龄ＳＤ雌性大鼠注射丙酸睾丸酮造成雄激素致不孕大鼠（ＡＳＲ），再灌服滋肾阴药后发现，ＡＳＲ卵巢多囊变，无黄体，体外睾酮产量增加，糖耐量下降，血雄激素和胰岛素水平升高，体重增加；滋肾阴药使ＡＳＲ卵巢增大并排卵，体外产生睾酮能力下降，糖耐量上升，血胰岛素和体重下降。结果提示ＡＳＲ的无排卵系高胰岛素血症与卵巢高雄激素血症共同作用所致；滋肾阴药通过降低ＡＳＲ体内胰岛素和雄激素水平而促排卵。
Male Sprague-Dawley (SD) rats were injected with testosterone propionate to induce androgen-sterilized rat (ASR) at 9 days of age. After reperfusion with Nourishing Kidney Yin, it was found that ASR ovarian cyst increased, Decreased blood androgens and insulin levels, weight gain; nourishing Yin drugs to ASR ovary increased and ovulation, testosterone production decreased in vitro, impaired glucose tolerance, blood insulin and body weight decreased. The results suggest that ASR caused by anovulatory hyperinsulinemia with androgenic hyperandrogenism caused by the interaction; Zishenyin by lowering ASR insulin and androgen levels and promote ovulation.