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目的探讨腹腔镜与孕三烯酮联合对子宫内膜异位症患者近期和远期的临床疗效。方法选取2013年1月-2015年1月收治的子宫内膜异位症患者100例,采用随机数字表法分为观察组和对照组,对照组采用单纯的腹腔镜手术干预,观察组在对照组基础上加用孕三烯酮激素口服,对比两组治疗6个月以及1年后临床症状改善率、妊娠率、术后复发率、并发症发生率以及药物不良反应等情况。结果观察组治疗后缓解率为88.0%,对照组缓解率为54.0%,两组缓解率存在统计学差异(χ2=14.03,P<0.01);观察组的复发率和并发症发生率均小于对照组(P<0.01),观察组妊娠率明显高于对照组(P<0.01);观察组治疗后疼痛评分降低至(2.3±0.2)分,明显低于对照组的(4.0±0.9)分,差异有统计学意义(P<0.05);随访1年后观察组复发率仅为4.0%,对照组为30.0%,两组复发率差异有统计学意义(P<0.01);观察组自然妊娠率为50.0%,对照组为10.0%,有统计学差异(P<0.01)。结论腹腔镜手术与孕三烯酮联合对子宫内膜异位症有明显的临床效果,并且具有长期获益的效果。
Objective To investigate the clinical efficacy of laparoscopy combined with gestrinone in patients with endometriosis in the short and long term. Methods 100 patients with endometriosis who were admitted from January 2013 to January 2015 were randomly divided into observation group and control group using random number table. The control group was treated with simple laparoscopic surgery. The observation group was compared with the control group Group Gestrinone on the basis of oral administration of hormones, compared two groups of 6 months after treatment and 1 year after the clinical improvement rate, pregnancy rate, recurrence rate, the incidence of complications and adverse drug reactions and so on. Results In the observation group, the remission rate was 88.0% and the remission rate was 54.0% in the control group. There was a significant difference between the two groups (χ2 = 14.03, P <0.01). The recurrence rate and complication rate in the observation group were less than those in the control group (P <0.01). The pregnancy rate in the observation group was significantly higher than that in the control group (P <0.01). The pain scores in the observation group were decreased to (2.3 ± 0.2) points and significantly lower than those in the control group (4.0 ± 0.9) The difference was statistically significant (P <0.05). After one year of follow-up, the recurrence rate was only 4.0% in the observation group and 30.0% in the control group, the recurrence rate was significantly different between the two groups (P <0.01) 50.0% in the control group and 10.0% in the control group (P <0.01). Conclusions Laparoscopic surgery combined with gestrinone has obvious clinical effect on endometriosis and has long-term benefit.