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替加色罗(tegaserod)为一种5-羟色胺4(5-HT4)受体部分激动剂,自问世以来已广泛应用于治疗便秘型肠易激综合征(C-IBS),并在临床应用中取得良好疗效。随着对胃肠道5 HT4受体及其亚型的深入研究和认识以及替加色罗的临床应用观察,发现替加色罗对于多种胃肠道功能性疾病均有一定的治疗作用,本文将就替加色罗的临床应用进展作一综述。
Tegaserod, a serotonin 4 (5-HT4) receptor partial agonist, has been widely used in the treatment of constipation-predominant irritable bowel syndrome (C-IBS) since its introduction and has been used clinically In the good effect. With the in-depth study and understanding of gastrointestinal 5HT4 receptor and its subtypes and the clinical application of tegaserod, we found that tegaserod has a certain therapeutic effect on a variety of gastrointestinal tract functional diseases, This article will review the progress of the clinical application of tegaserod.