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目的观察莫西沙星联合氨溴索雾化吸入治疗老年肺炎的疗效及安全性。方法选择2013年1月至2014年1月收治的老年肺炎患者85例,按照随机数字表法分为观察组(42例)和对照组(43例),两组患者均给予吸氧、解热镇痛、止咳平喘等常规治疗。在常规治疗基础上,观察组给予莫西沙星注射液静脉滴注,盐酸氨溴索注射液超声雾化吸入治疗。对照组给予盐酸左氧氟沙星注射液与盐酸氨溴索注射液静脉滴注治疗。两组疗程均为7 d。观察两组治疗效果及药物不良反应发生情况。结果观察组总有效率90.5%,明显优于对照组(65.1%)(P<0.05)。观察组发热消失时间、咳嗽咳痰消失时间、平均住院时间明显短于对照组(P均<0.05);病原菌清除率明显高于对照组(P<0.05);不良反应发生率少于对照组,但差异无统计学意义(P>0.05)。结论莫西沙星联合氨溴索雾化吸入治疗老年肺炎效果明显,临床指标改善明显,副作用小。
Objective To observe the efficacy and safety of moxifloxacin and ambroxol inhalation in the treatment of senile pneumonia. Methods Eighty-five elderly patients with pneumonia admitted between January 2013 and January 2014 were randomly divided into observation group (n = 42) and control group (n = 43) according to random number table. Both groups were given oxygen and antipyretic Analgesic, cough and asthma and other conventional treatment. On the basis of routine treatment, the observation group was given moxifloxacin injection intravenously and ambroxol hydrochloride injection by ultrasonic atomization. The control group was given levofloxacin hydrochloride injection and ambroxol hydrochloride injection intravenously. The two courses of treatment were 7 d. Observation of two groups of treatment and adverse drug reactions occurred. Results The total effective rate in observation group was 90.5%, which was significantly better than that in control group (65.1%) (P <0.05). The time of disappearance of fever, the disappearance of cough and expectoration, and the average length of stay in the observation group were significantly shorter than those in the control group (P <0.05). The clearance rate of pathogenic bacteria in the observation group was significantly higher than that in the control group (P <0.05) But the difference was not statistically significant (P> 0.05). Conclusion Moxifloxacin combined with ambroxol atomized inhalation for the treatment of senile pneumonia has obvious effect, obvious improvement of clinical indexes and little side effects.