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Objective To investigate the effect of frontotemporal rhytidectomy combined with botulinum toxin A type injection on lifting upper facial skin, improving upper facial skin aging, removing peri-orbital, glabellar and forehead wrinkles and strengthening the effect of rhytidectomy. Methods 20 patients with upper facial wrinkle plastic surgery, female, were designed with incision marking line along forehead and temporal hairline for dissection. The forehead was stripped along the superficial layer of periosteum, and the temporal part was stripped against the superficial surface of superficial temporal fascia. Then the suspension was used to tight the skin, the redundant skin tissue was removed, the cosmetic incision was sutured, the drainage device was placed routinely after the operation, and the pressure dressing is applied for 72 hours. The stitches were removed 7 days after the operation, at the same time , the appropriate dose of botulinum toxin type A was injected into the glabella, the outer cer of both eyes and the forehead to remove wrinkles and to rejuvenate the upper facial skin. Results 20 patients were followed up for 1-12 months, the results were all satisfactory. The upper skin relaxation was obviously improved, the forehead, glabellar and peri-orbital wrinkles were significantly reduced, the skin was plump and lustrous, the scar was hidden , not obvious and without complications after the incision was healed, and the upper facial skin showed obvious rejuvenation effect. Conclusion Frontotemporal rhytidectomy combined with botulinum toxin type A injection facial rejuvenation treatment is safe, effective, and has less complications as well as quick recovery, which is a feasible and good treatment.