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Congenital cleft lip is a common congenital defect. At present, surgical treatment is the only effective treatment for congenital cleft lip. Currently, there are many surgical methods for cleft lip. Many scholars continue to the improvement of surgical methods, and the immediate effect after surgery is significantly improved. However, despite the continuous improvement of surgical methods, lip and nose deformities are inevitably left after cleft lip. Because the lip occupies an important aesthetic position in the face, the restoration of secondary lip deformity after cleft lip surgery has important clinical significance. There are individual differences in secondary lip deformities in patients with cleft lip, and there are various methods of rehabilitation. There is no uniform treatment standard. This article mainly focuses on the current treatment progress of secondary lip deformities after cleft lip, especially autologous fat transplantation in secondary lip deformity after cleft lip is reviewed as follows.