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醋酸棉酚临床试用曾表明服药后主诉性功能减退者约占5％,动物实验亦表明棉酚对血浆睾酮生物合成有影响,但临床观察则均认为棉酚对血浆睾酮水平无明显影响,故棉酚所致性功能减退是否由于其对睾酮生物合成影响尚难肯定。曾报道棉酚具抑制睾酮刺激前列腺、精囊发育作用,但尚有争议。本文旨在以动物实验探讨棉酚抗雄激素作用及对睾酮受体影响。
Acetic acid gossypol clinical trials have shown that after taking the main complaint of hypogonadal function about 5%, animal experiments also showed that gossypol on plasma testosterone biosynthesis, but clinical observations were that gossypol no significant effect on plasma testosterone levels, so Whether gossypol-induced sexual dysfunction is due to its effect on testosterone biosynthesis is difficult to confirm. Gossypol has been reported to inhibit testosterone stimulation of the prostate, seminal vesicle development, but there is still controversy. The purpose of this article is to investigate the effects of gossypol on androgen and testosterone receptor in animal experiments.