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目的：研究妊娠期锰染毒对子代神经行为的影响。方法：选用转棒试验、被动回避性跳台实验和Ｍｏｒｉｓ水迷宫试验，观察妊娠期大鼠锰染毒，其子鼠１月龄和２月龄时神经行为的改变，同时检测了子鼠脑内多巴胺含量和中脑内锰的含量。结果：①７．５ｍｇ和１５ｍｇ染锰组的子鼠，其２月龄时的神经行为与正常组之间有着显著性的差异，其脑内多巴胺含量也明显低于正常对照组。②出生后２ｄ、１月龄和２月龄染锰组子鼠中脑锰含量显著高于正常组。结论：母体内过多的锰可通过胎盘进入胎儿体内并引起子代神经行为的改变，其机理与多巴胺神经递质的减少，脑锰含量的增高有关。实验说明发育中的神经系统对锰的神经毒性是敏感的
Objective: To study the effect of manganese exposure during pregnancy on the neurobehavioral behavior of offspring. Methods: The changes of neurobehavioral changes at 1 month and 2 months of age were observed in rats exposed to manganese by passive rotation test and Moris water maze test. Dopamine content and content of manganese in the brain. Results: (1) There was a significant difference between the neurons of rats of 2.5 mg and 15 mg manganese groups at 2 months of age and that of the normal group. The content of dopamine in the brain of the rats with 7.5 mg and 15 mg manganese groups was also significantly lower than that of the normal control group. (2) Manganese content in midbrain of rats of 2-month-old, 1-month-old and 2-month-old rats was significantly higher than that of normal group. Conclusion: Excess manganese in the mother’s body can enter the fetus through the placenta and cause neurobehavioral changes in offspring. The mechanism is related to the decrease of dopamine neurotransmitter and the increase of brain manganese content. Experiments show that the developing nervous system is sensitive to the neurotoxicity of manganese