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为了评价干扰素在免疫应答中的作用,作者对使用干扰素治疗的10例慢性丙型肝炎(CHC)和11例慢性乙型肝炎(CHB)患者的外周淋巴细胞亚群与肝内人白细胞抗原(HLA-1、HLA-2)和淋巴细胞亚群的表达作了比较研究。根据患者肌注重组α干扰素(rIFN-α)的剂量(3～18MIU,共4周)分为以下4组:(1)CHB(6)组(即每日肌注6MIU IFN)6例;(2)CHB(18)组5例;(3)CHC(3)组3例;(4)CHC(6)组7例。结果表明,在应用IFN治疗前,4组血清ALT水平没有统计学差异。CHC患者经IFN治疗2周后血清ALT平均水平明显下
In order to evaluate the role of interferon in immune responses, we investigated the association of peripheral lymphocyte subsets in 10 patients with chronic hepatitis C (CHC) and 11 patients with chronic hepatitis B (CHB) treated with interferon with intrahepatic human leukocyte antigen (HLA-1, HLA-2) and lymphocyte subsets were compared. The patients were divided into the following 4 groups according to the dosage of rIFN-α (3 ~ 18MIU for 4 weeks): (1) 6 cases of CHB (6 intramuscular injection) (2) 5 cases of CHB (18) group; (3) 3 cases of CHC (3) group; (4) 7 cases of CHC (6) group. The results showed that before the application of IFN treatment, 4 groups of serum ALT levels were not statistically different. The average level of serum ALT in patients with CHC after 2 weeks of IFN treatment was significantly lower