论文部分内容阅读
目的 观察人类微小病毒B19(HPVB19)宫内感染与早产儿、足月小于胎龄儿的关系。方法 采用ELISA方法对 35例早产儿、30例足月小于胎龄儿进行了血清HPVB19 IgM及IgG的检测 ,并将 4 8例正常新生儿脐血作为对照组。结果 35例早产儿中HPVB19 IgM阳性率为 2 8 5 7% (10 /35 ) ,30例足月小于胎龄儿组HPVB19 IgM阳性率为 2 3 33% (7/30 ) ,4 8例正常对照组中HPVB19 IgM阳性率为 4 17% (2 /48)。两组与正常对照组比较 ,差异有非常显著性意义 [χ2 =7 87,P <0 0 1,相对危险度 (RR) =6 84 ;χ2 =4 90 ,P <0 0 5RR =5 6 ]。结论 微小病毒B19宫内感染与早产的发生、胎儿宫内生长迟缓相关。
Objective To observe the relationship between intrauterine infection of human parvovirus B19 (HPVB19) and preterm infants and full term infants less than gestational age. Methods Serum HPVB19 IgM and IgG were detected in 35 premature infants and 30 full-term infants with gestational age by ELISA, and 48 normal neonates were used as control group. Results The positive rate of HPVB19 IgM in 35 preterm infants was 2 85.7% (10/35). The positive rate of HPVB19 IgM in 30 infants younger than gestational age group was 23 33% (7/30), and 48 cases were normal The positive rate of HPVB19 IgM in control group was 41.7% (2/48). The difference between the two groups was significant (χ2 = 7 87, P <0 01, relative risk (RR) = 6 84; χ2 = 4 90, P 0 05RR 5 56) . Conclusion Intrauterine parvovirus B19 infection is associated with the occurrence of prematurity and fetal intrauterine growth retardation.