论文部分内容阅读
采用高脂饮食喂养法建立兔Ａｓ模型研究了巴巴多斯芦荟对血脂、６酮前列腺素Ｆ１α（６ＫｅｔｏＰＧＦ１α）、血栓素Ｂ２、过氧化脂质（ＬＰＯ）含量、超氧化物歧化酶（ＳＯＤ）活性及主动脉粥样硬化斑块面积的影响。结果表明巴巴多斯芦荟冷冻干燥提取物０２ｇ／ｋｇ·ｄ灌服可明显升高Ａｓ兔６ＫｅｔｏＰＧＦ１α含量，降低ＬＰＯ含量，减小主动脉粥样硬化斑块面积，对血脂、血栓素Ｂ２的含量及ＳＯＤ活性无影响。表明巴巴多斯芦荟可预防兔实验性Ａｓ病变，该作用可能与其抗氧化及调节ＰＧＩ２／ＴＸＡ２平衡机制有关。
A high-fat diet feeding method was used to establish a rabbit As model. The effects of Aloe barbadensis on serum lipids, 6KetoPGF1α, thromboxane B2, lipid peroxidation (LPO) content, and superoxide dismutase were studied. (SOD) activity and the effect of aortic atherosclerotic plaque area. The results showed that the Ogasi extract of 0. 2g/kg·d of Aloe barbadensis could significantly increase the content of 6KetoPGF1α, decrease the content of LPO, and reduce the atherosclerotic plaque area of aorta. B2 content and SOD activity had no effect. It was shown that Aloe barbadensis can prevent experimental As lesions in rabbits, which may be related to its antioxidation and regulation of PGI2/TXA2 balance mechanism.