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目的：评价肾综合征出血热（HFRS）综合干预措施的流行病学效果。方法选取1996年-2008年牡丹江市连续高发5个县作为干预现场，采用实验流行病学方法，评价以疫苗免疫为主的综合干预措施的效果。结果实施综合干预措施后，5个干预试验县2009年-2012年HFRS发病水平持续下降，发病率由干预前的17．94/10万降到干预后的5．58/10万，保护率达93．54％。同时还取得了良好的经济效益。结论综合干预措施对控制肾综合征出血热的流行病学效果和经济效益显著。“,”Objective To evaluate the epidemiological effect of comprehensive intervention measure on HFRS.Methods five counties with the annual continuously high HFRS incidence were selected as experimental sites in Mudanjiang from 1996 to 2008,with the aid of experimental epidemi-ological method,to evaluate the effect of comprehensive measure predominated by vaccine immunization.Results Since the implementation of the com-prehensive measure in 5 counties,the incidence rate dropped continuously from 17.94/100 000 before intervention to 5.58/100 000 after intervention from 2009 to 2012, with the protection rate up to 93.54%.Meanwhile a good economic benefit was achieved.Conclusion The comprehensive HFRS intervention measures are effective in epidemiologic and economic benefit.