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瘤型麻风患者对麻风菌素的特异性无反应性的机制是麻风免疫学中的中心问题,同时也提供了一个探讨人体免疫调节机制的特殊机会.Mehra及其同事已证实瘤型(LL)和界线类(BB)麻风患者的外周血中有麻风菌素诱导的抑制性细胞,并认为这些细胞与无反应状态有关.然而,对这一重要观察颇有争议,因为其它试验室采用类似或不同的方法未能证实此发现,为此,作者为证实Mehra及其同事的发现,严格按她们的实验设计进行了重复试验,
The specific non-responsive mechanism of leprosy in patients with leprosy is a central issue in leprosy immunology and offers a unique opportunity to explore the mechanisms of immune regulation in humans .Mehra and colleagues have demonstrated that neoplasia (LL) And borderline (BB) leprosy-induced inhibitory cells in the peripheral blood of leprosy patients and considered them as non-responsive, however, this important observation is controversial because other laboratories use similar or Different approaches failed to confirm this finding, and to this end, in order to confirm the findings of Mehra and colleagues, the authors conducted a rigorous trial of their experimental design,