【摘 要】
：
Two new compounds,11,11 ’-dimer of scopoletin(1) and 11-O-β-glucopyranosylhamaudol(2),together with seven known compounds were isolated and identified from th
【机 构】
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School of Pharmaceutical Science, Shandong University,Xintai Institute of Skin Diseases,The Second H
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
Two new compounds,11,11 ’-dimer of scopoletin(1) and 11-O-β-glucopyranosylhamaudol(2),together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa.The chemical structures of the isolated compounds were elucidated using different spectroscopic methods.In addition,the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562/A02 cells.Compounds 1,8,and 9 were endowed with remarkable MDR reversing effects.
Two new compounds, 11,11 ’-dimer of scopoletin (1) and 11-O-β-glucopyranosylhamaudol (2), together with seven known compounds were isolated and identified from the whole grass of Cicuta virosa. Chemical structures of the isolated Compounds were elucidated using different spectroscopic methods. In addition, the chemical constituents were evaluated for multidrug resistance reversing activity towards doxorubicin-resistant K562 / A02 cells. Compounds 1,8, and 9 were endowed with remarkable MDR reversing effects.
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