米诺环素致色素沉着局限于皮下脂肪

• 作 者: Rahman Z. Lazova R. Antaya R.J. 李政霄
• 机 构: Internal Medicine Yale University School of Medicine,New Haven CT United States,
• 出 处: 世界核心医学期刊文摘(皮肤病学分册)
• 发表日期: 2005年11期
• 关键词: 米诺环素 皮下脂肪 色素沉着 局限 铁染色 组织学检查 寻常痤疮 阴性 色素 真皮

We present a 15-year-old girl with bilateral lower extremity discoloration of one-year duration while taking minocycline for acne vulgaris. The clinical characteristics best supported type II minocycline hyperpigmentation, but the histology revealed that the pigmentation was solely limited to the subcutaneous adipose tissue, completely sparing the dermis. Special stain for iron was negative. This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron.

We present a 15-year-old girl with bilateral lower extremity discoloration of one-year duration while taking minocycline for acne vulgaris. The clinical characteristics best supported type II minocycline hyperpigmentation, but the histology revealed that the pigmentation was solely limited to the subcutaneous adipose This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron.