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本文目的是探索药物经脂质体包裹后对大鼠体内吸收的影响.用薄膜法制备双硬脂酰磷脂酰胆硷/胆固醇和卵磷脂/胆固醇多层脂质体,用逆相蒸发法制备双硬脂酰磷脂酰胆硷/胆固醇大单层脂质体.测定游离的和脂质体包裹的PEG-4000、氢化可的松和水杨酸的排泄曲线.游离的或脂质体包裹的PEG-4000口服给药后,尿液中无放射性检出,表明脂质体包裹不能促进标记物吸收.口服游离氢化可的松或脂质体后,2天内可从尿中回收约15%的放射性,其中大部分是在前24h内出现.所用脂质体类型(多层或大单层)和其类脂的组成并不影响排泄形式.脂质体包裹对口服后氢化可的松的吸收程度和速度均无影响.水杨酸的研究是将标记物包入在胃肠道中最稳定的一种脂质体(双硬脂
The aim of this paper is to explore the effect of drug on the absorption in vivo after being encapsulated by liposomes.The bis-stearoylphosphatidyl choline / cholesterol and lecithin / cholesterol multilamellar liposomes were prepared by thin-film method and prepared by reverse-phase evaporation Distearoylphosphatidylcholine / Cholesterol macromer liposomes .Excretion curves of free and liposome-encapsulated PEG-4000, hydrocortisone and salicylic acid were determined. Free or liposome-encapsulated After oral administration of PEG-4000, no radioactivity was detected in the urine, indicating that liposomal encapsulation failed to promote label absorption.Orally, after free hydrocortisone or liposomes were administered orally, about 15% of Radioactivity, most of which occurred within the first 24 h.The composition of the liposomes used (multilayer or large monolayer) and their lipids did not affect the excretion form.Liposome-encapsulated absorption of hydrocortisone orally The degree and speed have no effect.Salicylic acid is the study of the marker into the most stable in the gastrointestinal tract of a liposome (distearyl