论文部分内容阅读
甲氨喋呤遇光不稳定,发生游离基机理的降解反应。稀释药物或加入碳酸氢盐可增加药物对光的不稳定性,0.5mg/ml的甲氨喋呤在融冻期间稳定,溶解于甲醇和乙醇的该药能吸附在玻璃器皿上,故应避免使用甲、乙醇。该药与血清白蛋白的结合很强,达94％。 5-氟尿嘧啶(5-FU)在碱性和紫外光下易降解,但高浓度的5-FU(50mg/ml)在棕色瓶中稳定期为8周。就生物分析而言,在冰冻状态下可稳定2周,在37℃介质中也相当稳定。 6-巯嘌呤对光和氧化反应敏感,在光的作
Methotrexate in case of light instability, the degradation of free radical mechanism of response. Dilution of drugs or adding bicarbonate can increase the instability of the drug on light, methotrexate 0.5mg / ml during thawing stable, dissolved in methanol and ethanol, the drug can be adsorbed on the glassware, it should be avoided Use A, ethanol. The drug and serum albumin combination of strong, up to 94%. 5-Fluorouracil (5-FU) is readily degradable under alkaline and UV light, but high concentrations of 5-FU (50 mg / ml) are stable in brown bottles for 8 weeks. For bioanalysis, it is stable for 2 weeks in the frozen state and quite stable in the medium at 37 ° C. 6-Mercaptopurine is sensitive to light and oxidation reactions, made in light