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近年来,随着越来越多的抗生素类药物、皮质类固醇激素和免疫抑制剂等广泛应用,真菌感染性疾病逐渐增多,从而抗真菌药物的缺乏成了一个紧迫问题.由于真菌是一种与它的宿主有相似结构和代谢过程的真核生物,因此抗真菌药物既能破坏真菌细胞也能破坏宿主本身,不象抗细菌药物仅仅在细菌细胞内起作用;而且大部分药物只在真菌细胞膜起作用,又相对不稳定,在生物体内易被溶解,故仅有一较窄的抗菌谱.所以,真菌性感染的治疗是一个极为复杂而棘手的问题.积极努力发现新的低毒而有效的抗真菌药物是我们应主动担负的责任.
In recent years, as more and more antibiotics, corticosteroids and immunosuppressive agents are widely used, the number of fungal infectious diseases gradually increases, so the lack of anti-fungal drugs has become an urgent problem.As the fungus is a Its host has a similar structure and metabolic processes of eukaryotes, anti-fungal drugs can destroy both the fungal cells can also damage the host itself, unlike antibacterial drugs only in bacterial cells play a role; and most of the drugs only in the fungal cell membrane Therefore, the treatment of fungal infections is a very complex and difficult issue. Active efforts to find a new low toxicity and effective Antifungal drugs are the responsibility we should take the initiative.