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近年,性激素与消化性溃疡(PU)是否相关,其在PU发病机理中起何作用,病程中有何变化等问题,已引起国内外一些学者的关注。1991～1994年我们测定了59例男性十二指肠溃疡病(DU)患者血清睾酮(T)、雌二醇(E_2)、泌乳素(PRL)、黄体生成素(LH)和卵泡刺激素(FSH)水平,现将结果报告如下,并对其临床意义略加探讨。 材料和方法 一、病例选择:59例住院经胃镜检查确诊的男性十二指肠溃疡(DU)活动期患者,年龄19～77岁,平均42.5岁。所有患者晨空腹卧位肘静脉采血5ml,分离血清,置-40℃贮存待检。其中20例经洛赛克20mg/d治疗4周后复查胃镜属疤痕期患者,再次复查血清性激素。对照组为健康男性69名,年龄20～69岁,平均39.6岁。 二、方法:血清T、E_2、PRL、LH及FSH均用放射免疫法测定,试剂盒由天津DPC公司提供。结果以(?)±S表示,经t检验及直线相关分析处理。 结果 DU活动期患者血清T、E_2、LH及FSH均明显降低,与对照组相比较,差异显著(P均<0.05）。血清T与E_2;LH与T呈正相关(r=0.60,p<0.05;r=
In recent years, sex hormones and peptic ulcer (PU) is related to its pathogenesis in the PU play any role in the course of what changes and other issues, has attracted the attention of some scholars at home and abroad. From 1991 to 1994, we measured the levels of serum testosterone, estradiol (E2), prolactin (PRL), luteinizing hormone (LH) and follicle stimulating hormone (IL) in 59 patients with duodenal ulcer disease FSH) levels, the results are reported as follows, and its clinical significance of a little discussion. Materials and methods A case selection: 59 cases of duodenal ulcer (DU) active patients diagnosed by gastroscopy hospitalized, aged 19 to 77 years, mean 42.5 years old. All patients morning fasting supine vein blood 5ml, serum was separated, set -40 ℃ storage to be tested. Among them, 20 cases were treated by Losec 20mg / d for 4 weeks and were examined by gastroscope in patients with scar stage. Serum sex hormones were reviewed again. The control group of 69 healthy men, aged 20 to 69 years, mean 39.6 years. Second, methods: Serum T, E_2, PRL, LH and FSH were determined by radioimmunoassay, the kit provided by the Tianjin DPC company. The results were (?) ± S, t-test and linear correlation analysis. Results The serum levels of T, E_2, LH and FSH in patients with DU active stage were significantly lower than those in control group (all P <0.05). Serum T and E 2; LH and T were positively correlated (r = 0.60, p <0.05; r =