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3例患者均为中老年男性,皮疹多泛发全身或仅累及双下肢,合并2型糖尿病、乙肝小三阳、高血压、高血脂、肾功能衰竭等疾病.临床均表现为丘疹、结节,中央可见脐状凹陷,内填充角栓.组织病理检查示表皮呈杯形下陷,下方为坏死变性的胶原和白细胞碎屑,坏死胶原从表皮穿出.诊断:反应性穿通性胶原病.给予阿维A、沙利度胺、火把花根等药物或(和)抗生素软膏外用治疗后有效.“,”Three cases of reactive perforating collagenosis were reported.The patients were middle-aged and elderly men,whose rashes were all over the body or on the both lower extremitities.At the time of presentation,there were numerous dome-shaped nodules,which had a central umbilication containing firm keratotic plugs.The three patients were associated with some systemic diseases,such as type 2 diabetes,hepatitis B,hypertensive disease,hyperlipemia,renal failure and so on.Histopathology showed a cup-shaped plug over degenerative collagen and leucocye patches in the epidermis,which was interlinked with dermis.The diagnosis was made as reactive perforating collagenosis.It was effective that oral use of retinoid and thalidomide.