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目的 探讨吸入一氧化氮 (NitricOxide,NO)在实验性胎粪吸入综合征中 ,对机体止血功能的影响。 方法 对机械通气下的健康成年新西兰白兔 ,随机分为模型组、对照组及治疗组 ,以气管插管 ,机械通气方式吸入NO ,浓度为 2 0× 10 - 6 (2 0ppm)。观察NO吸入前 0时点及吸入后 1h血小板最大聚集率 (PAgTmax) ,出血时间 (BT) ,血小板计数 (PLT)的变化。 结果 实验兔吸入NO后 ,出现血小板聚集率下降 ,治疗组在吸入NO后 1h ,PAgTmax下降 45 % (P <0 0 1) ,出血时间延长 47% (P <0 0 1)。血小板含量下降差异不显著。 结论 实验兔吸入NO ,血小板聚集率降低 ,出血时间延长
Objective To investigate the effect of inhaled nitric oxide (NO) on the hemostatic function in experimental meconium aspiration syndrome. Methods Healthy adult New Zealand white rabbits under mechanical ventilation were randomly divided into model group, control group and treatment group. Endotracheal intubation and mechanical ventilation were used to inhale NO with a concentration of 20 × 10 -6 (20ppm). The changes of PAgTmax, BT and PLT at 0 o’clock before inhalation and 1h after inhalation were observed. Results After inhalation of NO, the platelet aggregation rate of the experimental rabbits decreased. The PAgTmax decreased 45% (P <0.01) and the bleeding time prolonged 47% (P <0.01) 1 h after inhalation of NO in the experimental group. The difference of platelet content was not significant. Conclusion The experimental rabbits inhaled NO, reduced platelet aggregation rate, prolonged bleeding time