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MN抗原决定簇是由寡糖和多肽构成的唾液酸糖蛋白，寡糖和多肽在结构上存在差异。这些差异由1组基因控制的［1,2］。多肽部分的差异由第4号染色体上的1对等位基因（Gly－cophorinA，GPA）决定，编码区3个核苷酸的差异导致了肽链N末端第1位和第5位氨基酸差异，第1位氨基酸M型为丝
The MN antigenic determinant is a sialic acid glycoprotein composed of oligosaccharides and polypeptides that differ structurally in structure. These differences are controlled by a set of genes [1,2]. The difference in the part of the polypeptide is determined by a pair of alleles (Gly-cophorin A, GPA) on chromosome 4. The difference of 3 nucleotides in the coding region leads to amino acid differences at the N-terminal of the peptide chain, The first amino acid M-type silk