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目的探讨细胞块免疫细胞化学在胸腹水细胞学诊断中对提高肿瘤细胞阳性率、鉴别细胞良恶性、确定肿瘤细胞来源的临床意义。方法回顾性分析收集的65例胸腹水涂片、细胞块和免疫细胞化学诊断,并结合相关临床病史。结果 65例胸腹水中有3例涂片中仅见几个肿瘤细胞,而细胞块为阴性,其余62例标本涂片与细胞块检查结果完全相符;其中13例良性病变标本细胞涂片及细胞块均未查到肿瘤细胞或可疑细胞,报告阴性;49例可疑阳性标本或需鉴定恶性肿瘤细胞来源的,通过免疫细胞化学均得到准确结果。结论细胞块免疫细胞化学在胸腹水肿瘤细胞学诊断中对细胞良恶性的鉴别和鉴别组织来源具有良好的应用价值,值得推广,但对提高阳性率方面细胞块不及普通涂片,二者相互对照观察有助于提高判断结果准确性,对于细胞块及免疫细胞化学的应用应注意与临床资料及细胞学形态相结合,做到合理选择,合理应用。
Objective To investigate the clinical significance of cell immunocytochemistry in the diagnosis of pleural and ascitic fluid cytology to improve the positive rate of tumor cells, identify the malignant cells and determine the source of tumor cells. Methods A retrospective analysis of 65 cases of pleural effusion smear, cell mass and immunocytochemistry diagnosis, combined with the relevant clinical history. Results There were only a few tumor cells in three samples of pleural effusion and ascites in 65 pleural and ascitic fluids, while the negative ones were in the smear. The remaining 62 specimens were completely consistent with the results of cell mass examination. Thirteen of them were smear and cell mass Neither tumor cells nor suspicious cells were found, and the report was negative; 49 cases of suspected positive samples or malignant tumor cells need to be identified, and get accurate results by immunocytochemistry. Conclusion The immunocytochemistry of cell mass in the diagnosis of ascites and pleural effusion cytological diagnosis of benign and malignant cells and identify the source of tissue has a good value, it is worth promoting, but to improve the positive rate of the cell block is less than the normal smear, the two control Observation helps to improve the accuracy of the judgment. The application of cell mass and immunocytochemistry should be combined with clinical data and cytology to make reasonable choice and reasonable application.