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观察硝酸异山梨酯和尿激酶合用及单用尿激酶治疗急性心肌梗死的临床效果。方法:40例患者随机分成两组,治疗组和对照组各20例。治疗组用硝酸异山梨酯与尿激酶,对照组单用尿激酶,其它治疗两组无差异。所有病例采用常规生化自动仪测定心肌酶及常规心电图机做全导心电图。结果:治疗组胸痛缓解的时间为40±20分钟,发病至CPK峰值时间为13±4.5小时,CPK峰值为642±48U/L;上述这些项目对照组分别为60±14分钟、20±7小时、1022±71U/L,两组比较有显著差异(P<0.05),而抬高的ST-T下降总和两组无显著差异(P>0.05)。结论:硝酸异山梨酯和尿激酶治疗急性心肌梗死,可使胸痛缓解时间及到达CPK峰值时间明显缩短,CPK峰值明显下降。
To observe the clinical effect of isosorbide dinitrate combined with urokinase and urokinase alone in the treatment of acute myocardial infarction. Methods: Forty patients were randomly divided into two groups, 20 cases in each treatment group and control group. The treatment group with isosorbide dinitrate and urokinase, the control group urokinase alone, no difference in other treatment groups. All cases using conventional biochemical automatic determination of myocardial enzymes and conventional electrocardiogram machine to do all-lead ECG. Results: The relief time of chest pain in treatment group was 40 ± 20 minutes, the peak time of CPK was 13 ± 4.5 hours and the peak value of CPK was 642 ± 48U / L in the treatment group. The control group of these items were 60 ± 14 minutes and 20 ± 7 hours respectively , 1022 ± 71U / L, there was a significant difference between the two groups (P <0.05), while there was no significant difference between the two groups (P> 0.05). Conclusion: Isosorbide dinitrate and urokinase in the treatment of acute myocardial infarction can relieve the time of chest pain and reach the peak of CPK significantly shortened, CPK peak decreased significantly.