APOPTOSIS OF DIFFERENT MYOCARDIAL CELLS CONTRIBUTES TO LEFT VENTRICULAR REMODELING IN SPONTANEOUSLY

• 作 者: 陈卫兵 秦永文
• 出 处: China Medical Abstracts(Internal Medicine)
• 发表日期: 2001年01期
• 关键词: hypertensive spontaneously remodeling Apoptosis minutes Kyoto assessed sections

Objective To study the change and role of apoptosis in hypertensive left ventricular remodeling. Methods Hearts from 16-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats(WKY) were investigated. Apoptosis in left ventricle sections was assessed by in situ end-labeling technique(TUNEL), the feature and type of cells undergoing apoptosis were identified uitrastructurally by transmission electron microscope (ECM). Additionally, localization of Fas protein-a mediator of apoptotic cell death was ex-

Objective To study the change and role of apoptosis in hypertensive left ventricular remodeling. Methods Hearts from 16-week-old spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) were investigated. Apoptosis in left ventricle sections was assessed by in situ end-labeling technique (TUNEL), the feature and type of cells undergoing apoptosis were identified uitrastructurally by transmission electron microscope (ECM). Additionally, localization of Fas protein-a mediator of apoptotic cell death was ex-