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目的:评价甘草酸二铵磷脂复合物注射剂(DG-PC)的对急性、慢性免疫性肝脏损害的保护作用。方法:大鼠腹腔注射四氯化碳、C57BL/6 J小鼠注射氨基半乳糖和Freund完全佐剂(FCA)分别复制急性和慢性肝脏损害模型,测定血清ALT、AST,并对肝脏进行病理学观察。结果:DG-PC能降低急性肝损大鼠ALT水平(P<0.05)和慢性肝损伤小鼠的AST水平(P<0.01)。急性肝损伤大鼠肝组织评分结果显示DG-PC能显著降低四氯化碳染毒肝脏组织的病理评分(P<0.01),DG和模型组没有差异。肝组织切片光镜和电镜观测均显示,DG-PC可以改善急慢性肝损伤导致的肝细胞变性和损伤。结论:DG-PC对于大鼠急性化学性肝损伤和C57BL/6 J小鼠慢性免疫性肝损伤均具有一定的保护作用。
Objective: To evaluate the protective effect of diammonium glycyrrhizinate phospholipid complex injection (DG-PC) on acute and chronic immune liver damage. METHODS: Acute and chronic hepatic damage models were duplicated by intraperitoneal injection of carbon tetrachloride and C57BL/6 J mice injected with galactosamine and Freund complete adjuvant (FCA) respectively. Serum ALT, AST were measured, and liver pathology was performed. Observed. RESULTS: DG-PC could reduce the ALT levels in acute liver injury rats (P<0.05) and the AST levels in chronic liver injury mice (P<0.01). The liver tissue scores of acute hepatic injury rats showed that DG-PC could significantly reduce the pathological scores of carbon tetrachloride-exposed liver tissues (P<0.01). There was no difference between DG and model groups. Observation of light and electron microscopy of liver tissue sections showed that DG-PC can improve liver cell degeneration and damage caused by acute and chronic liver injury. Conclusion: DG-PC has protective effects on acute chemical liver injury in rats and chronic immunological liver injury in C57BL/6 J mice.